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Carlos R Morales is a Professor in the Department of Anatomy and Cell Biology at McGill University. His research focuses on cell and molecular biology, particularly on lysosomal biogenesis and the mechanisms involved in the targeting of lysosomal proteins. He investigates lysosomal sphingolipid activator proteins (SAPs) and their role in the pathogenesis of various lysosomal storage disorders. Dr. Morales is studying intracellular transport mechanisms of lysosomal hydrolases and is interested in how these proteins contribute to cellular function and disease pathology. His laboratory employs genetically modified mice to understand the effects of gene inactivation on lysosomal hydrolases linked to well-known lysosomal storage disorders. Furthermore, he is exploring the hypothesis that antimicrobial peptides linked to lysosomal targeting motifs can be effectively delivered to the lysosomal compartment, and he aims to evaluate novel therapeutic approaches for intercepting and eliminating pathogens within the endolysosomal compartment of infected cells.
Department: Department of Medicine. Program: Experimental Medicine.