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Carson Thoreen is an Associate Professor in the Department of Cellular and Molecular Physiology at Yale School of Medicine. He earned his PhD from the Massachusetts Institute of Technology in 2008 and a Bachelor of Science in Biology from Brown University in 2000. His research focuses on the mammalian target of rapamycin (mTOR) pathway, a master regulator of cell growth that plays vital roles in metabolism, aging, and cancer. The mTOR pathway is known to sense nutrient and growth signals, regulating key metabolic pathways, especially mRNA translation. Thoreen's findings indicate that acute inhibition of mTOR selectively impacts the translation of a large class of mRNAs with a terminal oligopyrimidine (TOP) motif, disrupting the mRNA cap-binding complex, eIF4F. He aims to unravel the mTOR-regulated translational mechanisms and their molecular details, as well as the characteristics of mRNAs that determine mTOR activity dependence, which has important physiological implications.
Yale School of Medicine • New Haven, CT
Leading research in cellular and molecular physiology with a focus on the mTOR pathway.
GRE is optional for PhD applicants. TOEFL speaking scores below 26 or IELTS speaking below 7.5 may require summer English training.