Dr. Cecilia Canessa

Biography

Cecilia Canessa, MD, is a Professor in the Department of Cellular and Molecular Physiology at Yale University. Her research focuses on the examination of the structure, function, and regulation of sodium channels, including the Epithelial Na+ Channel (ENaC) and Acid Sensing Ion Channels (ASICs). The ENaC channel is vital for sodium absorption in the kidney, lung, and colon, and mutations in ENaC genes can lead to disorders affecting whole-body sodium balance, characterized by hypertension and sodium wasting. Her current work investigates the mechanisms regulating the activity and expression of ENaC in epithelial cells, with a focus on the role of serum-and glucocorticoid-induced kinase Sgk1. Additionally, Canessa studies the biophysical properties and gating mechanisms of ASICs, which are expressed in neurons of the central and peripheral nervous systems and are relevant for nociception and synaptic transmission. Utilizing various experimental approaches, including electrophysiology techniques and genetic modifications, Canessa contributes significantly to the fields of nephrology and physiology.

Research Interests