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Cecilia Jönsson is a Principal Research Engineer at Linköping University specializing in chronic liver disease, particularly steatotic liver disease. Her research aims to understand the development and progression of chronic liver conditions at the molecular level, with a focus on identifying biomarkers for early detection. Overweight and obesity are recognized as primary risk factors for developing metabolic dysfunction-associated steatotic liver disease, whereby fat accumulates in the liver, leading to inflammation and fibrosis. The progression of fibrosis can result in liver cirrhosis and potentially fatal complications such as hepatocellular carcinoma. Despite advances, the molecular mechanisms behind liver fat accumulation and its progression to advanced liver disease are not fully understood, and existing blood-based biomarkers are insufficient for diagnosing steatotic liver disease. Jönsson conducts prospective studies utilizing mass spectrometry and NMR techniques to discover circulating molecules that indicate the extent of liver fat and fibrosis. Her work also includes developing an ex vivo model system for metabolic flux analysis to enhance the understanding of liver function and disease progression.
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