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Celia Berkers is a Professor at Utrecht University where she leads the Berkers group, focusing on metabolomics and studying small molecule metabolite profiles in cells via mass spectrometry. The group employs a mechanistic metabolomics strategy, performing metabolic tracer studies with various stable-isotope nutrients, and combines these with targeted metabolism-oriented proteomics studies to gain mechanistic insights into cellular metabolism. Her research emphasizes applying metabolomics tools in biomedical frameworks, specifically in investigating metabolism-mediated drug resistance and immuno-metabolism. The lab examines targetable metabolic changes in drug-resistant cancer cells, studies the metabolic mode of action of drugs, and seeks to provide insights into adverse drug effects. In particular, the group investigates proteasome inhibitors, which show promise in cancer treatment but are associated with resistance mechanisms. Furthermore, Berkers is involved in an Institute Chemical Immunology project aimed at developing metabolomics strategies to map metabolic differences in T cells, with the ultimate goal of identifying metabolic targets that can be selectively modulated to influence T-cell activity.
Department of Psychology