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Champak Chatterjee is a Professor at the University of Washington in the Departments of Chemistry and Pharmacology. His research focuses on the regulation of human chromatin structure and function, particularly concerning post-translational modifications (PTMs) of core histone proteins and the tumor suppressor protein p53. The Chatterjee lab specializes in developing and applying novel chemical and biochemical tools to investigate how various modifications like methylation, acetylation, ubiquitylation, and sumoylation affect gene transcription through RNA polymerase II. Professor Chatterjee's work aims to elucidate the mechanistic contributions of post-translationally modified proteins to critical cellular processes, gene transcription, and the regulation of proteomes, which is important for understanding normal human development and identifying potential therapeutic targets for diseases arising from the misregulation of PTMs. His lab operates at the intersection of chemical and molecular biology, utilizing a combination of methods to explore uniformly modified proteins in well-defined biochemical systems, enabling them to investigate important families of nuclear proteins that are implicated in various cancers.
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