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Changting Xiao is an Assistant Professor at the College of Medicine, University of Saskatchewan, specializing in Anatomy, Physiology, and Pharmacology. His research focuses on lipid and lipoprotein metabolism, gastrointestinal physiology, and the pathophysiology of metabolic disorders such as type 2 diabetes, obesity, and metabolic syndrome. Dr. Xiao emphasizes the growing epidemic of metabolic-related diseases, particularly their association with lipid lipoprotein abnormalities that heighten the risk of atherosclerotic cardiovascular disease (ASCVD). His research aims to gain mechanistic insights into the physiology and pathophysiology of metabolic disorders to enhance health outcomes. The lab employs integrative physiology and systems biology approaches to investigate the molecular mechanisms controlling lipoprotein secretion from the small intestine and liver using animal models. Dr. Xiao's specific interests include identifying and characterizing novel molecules such as gut hormones and cellular proteins involved in chylomicron synthesis and secretion. His lab seeks to elucidate the mechanisms through which genetic and environmental factors contribute to lipoprotein abnormalities linked to ASCVD and aims to identify potential drug targets for treating dyslipidemia.
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