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Dr. Charles S. Abrams is a Francis C. Wood Professor in the Perelman School of Medicine at the University of Pennsylvania, specializing in the field of Medicine. His research expertise lies in phospholipid signaling and its implications for inappropriate platelet activation, which contributes to vascular diseases such as stroke and myocardial ischemia. His laboratory focuses on the roles of pleckstrin and lipid kinases in platelets, investigating the effects of pleckstrin phosphorylation and its critical lipid-binding residues. Over the past few years, Dr. Abrams' lab has demonstrated pleckstrin's influential role in the reorganization of both platelets and lymphocyte cytoskeletons. The lab employs molecular and cellular biological techniques to explore blood cell biology, including mutagenesis, single-cell microinjection, and genetic library screening. Their ongoing projects aim to elucidate the pathways initiated by G-protein coupled receptors leading to actin reorganization, with research personnel including postdoctoral fellows and undergraduate students contributing to these investigations.
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