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Charles S. Abrams, M.D., is a Francis C. Wood Professor in the Department of Medicine at the University of Pennsylvania. His research focuses on phospholipid signaling in platelets and T-cells, particularly exploring inappropriate platelet activation associated with vascular diseases such as stroke and myocardial ischemia. His laboratory conducts studies to understand the roles of pleckstrin and lipid kinases in platelets. Notably, pleckstrin has emerged as a critical component in the reorganization of the cytoskeleton within both platelets and lymphocytes. The laboratory utilizes molecular and cellular biological techniques to investigate blood cell biology, including expression mutagenesis, single-cell microinjection, genetic library screening, and murine homologous gene targeting. Ongoing projects aim to elucidate the mechanisms by which phospholipid kinases and G-protein coupled receptors regulate actin reorganization. His work has been instrumental in advancing the understanding of platelet signaling pathways.
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