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Charles Holmes is a Professor in the Department of Biochemistry at the University of Alberta. His research focuses on reversible protein phosphorylation, which is a principal mechanism of intracellular signal transduction linked to external stimuli in eukaryotes. His work investigates how the actions of protein kinases and phosphatases regulate physiological processes. Specifically, Professor Holmes explores regulatory enzymes that play key roles in mediating hormone action, growth factor signaling, tumor suppression, and cell division. His major research systems include studying the regulation of protein phosphatases through inhibitor proteins and cyclic peptide toxins, as well as utilizing marine phytoplankton as a model system to examine signal transduction pathways involving these proteins. Professor Holmes' laboratory is equipped with high-performance liquid chromatography and capillary electrophoresis facilities, highlighting his commitment to advanced molecular biology techniques. He collaborates extensively on the structural biology aspects of his research program with international groups in the field.
Department: Mechanical Engineering and Engineering Management