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Dr. Charles (Chaz) Hong is a physician-scientist and entrepreneur currently serving as the Chair of the Department of Medicine and a Research Foundation Distinguished Professor at Michigan State University College of Human Medicine. He is recognized as a pioneer in the field of chemical genetics and embryonic development. Dr. Hong has used a multidisciplinary approach to elucidate the opposing roles of PI3K (Phosphatidylinositol 3-Kinase) and ERK signaling in artery-vein specification. His discoveries have led to significant advancements in the treatment of venous malformation syndromes through the application of PI3K inhibitors. He also contributed to the invention of dorsomorphin, a small-molecule inhibitor that has reshaped the understanding of BMP signaling pathway in development and disease processes. Additionally, his research includes generating human neural tissues from pluripotent stem cells, which aids in neurologic disease modeling. His innovative work has revealed a novel cancer survival pathway related to the Warburg Effect, leading to potential strategies for inducing ferroptosis in glioblastoma. Dr. Hong's academic background includes a graduate MD-PhD program from Yale and clinical training at Massachusetts General Hospital. Before joining MSU, he held faculty positions at Harvard Medical School, Vanderbilt University, and directed the inherited heart disease center at the University of Maryland.
Department of Medicine, Michigan State University • East Lansing, MI
Chair of the Department of Medicine, responsible for leading a transformative period of discovery and innovation.
Harvard Medical School • Cambridge, MA
Faculty member focusing on chemical biology.
Inherited Heart Disease Center, University of Maryland School of Medicine • Baltimore, MD
Directed the center specializing in inherited heart diseases.
Department of Psychology