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Charles T Lauhon is an Associate Professor at the School of Pharmacy, University of Wisconsin. His major research interest lies in biochemistry, specifically tRNA modification. His work focuses on how protein enzymes modify individual bases of tRNA, highlighting particularly interesting substrates like single nucleotides in the context of large, highly structured tRNA molecules. Lauhon studies how these enzymes are able to recognize nucleotides modified by surrounding RNA structure and investigates the simple chemical nature of tRNA base modifications, which are crucial for maintaining the fidelity of translation. Notably, these enzymes are required for biosynthesis and represent unique reaction mechanisms. Modifications in bacteria are critical for viability, presenting potential targets for antibiotic development. Lauhon applies mechanistic enzymology to study transformations using organic chemistry for the synthesis of alternate substrates and inhibitors, along with molecular biology to probe RNA substrate specificity. His current research focuses on rational design strategies for the discovery of antibiotics that target tRNA modification enzymes in bacteria.
School of Pharmacy, University of Wisconsin • Madison, WI
Joined faculty in the fall of 1996, focusing on research in biochemistry and tRNA modification.
Professional Option (MSPO) focused on applied economics and data analysis.