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Charlie Arber's work focuses on modeling Alzheimer's disease using human stem cells. He generates models of dementia using patient-derived fibroblasts and employs cellular reprogramming techniques in conjunction with CRISPR/Cas9 genome editing technologies. His research utilizes induced pluripotent stem cells (iPSCs) to generate neurons, organoids, astrocytes, and microglia. These models are crucial for understanding the underlying causes of neurodegeneration and dementia, with a specific emphasis on the biology of Amyloid beta and neuroinflammation.
Queen Square Institute of Neurology • United Kingdom
Conducting research on neurodegenerative diseases, focusing on Alzheimer's disease using human stem cells.