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Chirlmin Joo advanced single-molecule techniques innovating new tools for single-molecule multi-color FRET, single-molecule protein pull-down, and single-molecule protein sequencing. He applies these techniques for mechanistic studies of biological systems, focusing on the mechanistic properties of proteins, including those of the CRISPR Argonaute families. His group unraveled the target search mechanisms of Argonaute and Cas9 proteins and demonstrated vital roles in microRNA biogenesis and CRISPR adaptation at the single-molecule level. Additionally, Joo is developing a pioneering massively parallel single-molecule fluorescence method that integrates next-generation DNA sequencing, allowing genome-wide studies of single-molecule kinetics related to gene regulation and CRISPR-based genome engineering. Joo's work also explores the development of high-resolution single-molecule techniques that can determine protein sequences, leveraging single-molecule fluorescence nanopores to study protein translocation biophysics. He aims to create novel technologies for single-cell proteomics and real-time medical diagnostics. Notable awards include the 2019 Human Frontier Science Program Research Grant and the 2018 ERC Consolidator Grant.
Delft University of Technology • Delft, Netherlands
Leading research in single-molecule biophysics and developing innovative techniques for studying biological systems.
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