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Christian Kaiser is a professor of Molecular Biophysics and Biochemistry at Utrecht University. His research focuses on the fundamental aspects of protein biogenesis, specifically the processes by which proteins fold into their functional structures, avoiding misfolding and aggregation. Through the use of single-molecule optical tweezers and live-cell experiments, his work investigates how proteins interact with molecular chaperones during co-translational folding at the ribosome, revealing the intricacies of cellular protein folding and its implications for neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Kaiser's innovative high-throughput reporter assay technology allows for the observation of nascent chain folding in both bacterial and mammalian cells, paving the way for new insights into the complexities of protein folding mechanisms in multicellular organisms. His research not only enhances the understanding of basic biological processes but also stimulates the development of therapeutic strategies aimed at maintaining protein homeostasis in health and disease.
Department of Psychology