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Christina Jacobsen is an Assistant Professor in the Department of Pediatrics at Boston Children's Hospital. Her research focuses on pediatric osteoporosis, particularly understanding the genetic and developmental mechanisms that contribute to this condition in children. Christina's work uses rare genetic bone disorders as models to elucidate the underlying biology of bone growth and to develop novel therapeutic targets. Specifically, her laboratory studies Osteogenesis Imperfecta (OI), a genetic disorder characterized by brittle bones due to mutations in collagen genes. Through her research, she aims to identify patients at risk of osteoporosis and work towards treatment strategies that will help prevent fractures and other complications associated with this condition. Her lab employs advanced genetic models, including mouse and zebrafish, to investigate the phenotypic variations in OI and explore modifying mutations that could influence disease outcomes. Christina is also involved in clinical studies to connect genetic insights from her preclinical work with real-world applications for OI patients.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).