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Dr. Christine Bear's laboratory focuses on understanding the molecular basis of ion channel activity, with significant research interests in cystic fibrosis and kidney disease. She completed her postdoctoral training in patch clamp electrophysiology, yielding insights into mechanisms underlying single ion channel activity. The laboratory has collaborated with Dr. Jack Riordan to provide direct evidence that CFTR, the cystic fibrosis transmembrane conductance regulator, functions as a cyclic AMP regulated chloride channel. Her work has been pivotal in elucidating the mechanisms of action for protein intrinsic defects caused by mutations in CFTR genes. Additionally, her lab contributes to the broader field regarding membrane protein assembly, function, and novel methods of membrane protein purification and reconstitution. Currently, she is involved in collaborations to develop methodologies for measuring channel function in epithelia differentiated from iPS cells. In her renal disease research, she investigates the roles of mutations in the ClC-5 chloride/proton antiporter related to Dent's disease, aiming to understand how these mutations affect protein reabsorption in the kidney and identify potential therapeutic targets.
Hospital for Sick Children • Toronto, Ontario, Canada
Leading research on cystic fibrosis and kidney disease, focusing on ion channel activity and membrane proteins.
Department of Sociology