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Christopher Burge applies a combination of experimental and computational approaches to understand the regulatory codes underlying pre-mRNA splicing and types of post-transcriptional gene regulation. His research focuses on understanding the code of RNA splicing, including the precise locations where introns are spliced from primary transcripts and how specificity changes based on different cell types. His work involves mapping RNA-binding affinity spectra of dozens of human RNA-binding proteins, integrating this information with in vivo binding activity data. He also studies the functions of the 3’ untranslated regions and their roles in mRNA localization and microRNA regulation. Burge’s lab uses a combination of computational and experimental methods to address these significant questions.
MIT • Cambridge, MA