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Christopher Glass is a prominent researcher at the University of California, San Diego, where he leads the Glass Laboratory. His research focuses on the transcriptional mechanisms that regulate the development and function of macrophages, which are critical to immunity and inflammatory diseases. The laboratory employs a combination of biochemical, cellular, and genetic model systems to explore how sequence-specific transcription factors and associated co-regulators operate at gene-specific and genome-wide scales. Current projects include understanding enhancer selection and function, investigating macrophage lineage-determining factors like PU.1 and NFkB, and utilizing genome-wide approaches to define the mechanisms by which developmental origins and tissue environments dictate mouse and human macrophage functions. Glass’s team also exploits natural genetic variation within inbred mouse strains to elucidate transcription factor networks in macrophages, extending their insights to human disease phenotypes. Additionally, the lab is pioneering machine learning formulations to discover structures within multi-omic data, enhancing the understanding of macrophage signaling and enhancer function.
Administered by the Scripps Institution of Oceanography. Curricular groups include Climate-Ocean-Atmosphere (COAP), Geosciences (GEO), and Ocean Biosciences (OBP).