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Dr. Christopher Lee Holley is an Associate Professor in the Department of Medicine and the Department of Molecular Genetics and Microbiology at Duke University. His research focuses on the role of non-coding RNA (ncRNA) in cardiovascular health and disease, particularly small nucleolar RNA (snoRNA). Dr. Holley has made significant contributions to the understanding of the biological role of Rpl13a snoRNAs in regulating reactive oxygen species (ROS) and oxidative stress. His lab has identified four snoRNAs (U32a, U33, U34, U35a) critical for the oxidative stress response to various stimuli, including saturated fatty acids and doxorubicin. His current research is examining the role of snoRNAs in atherosclerosis, and he is actively pursuing translational research opportunities to design RNA therapeutics targeting snoRNAs for potential clinical use. With a diverse range of educational experiences, including a Cardiovascular Research Fellowship at Washington University, Dr. Holley has a strong background in both clinical and research settings.
Duke University • Durham, NC
Associate Professor in the Department of Medicine and Department of Molecular Genetics and Microbiology.
Washington University, School of Medicine • St. Louis, MO
Emphasized roles in research and mentoring related to cardiovascular health.
Department of Biomedical Engineering (MS program)