Dr. Christopher Nelson

Biography

Dr. Christopher Nelson is an Associate Professor at the University of Victoria, specializing in the study of transcription, RNA metabolism, and DNA repair pathways. His research focuses on how eukaryotic cells utilize histone proteins to package DNA into nucleosomes, which are the fundamental subunits of chromatin. His lab explores the assembly of nucleosomes and higher-order states that facilitate significant DNA compaction, thereby restricting access to the genetic template. A primary aim of his research is to understand how enzymes involved in transcription can overcome the barriers presented by nucleosomes and higher-ordered chromatin. The Nelson lab employs various models, such as Saccharomyces cerevisiae (budding yeast) and cultured human cells, to identify and dissect chromatin regulatory pathways that control transcription processes. Currently, Dr. Nelson's research is centered on a unique family of enzymes known as peptidyl-proline isomerases (PPIs), which modify protein folding by catalyzing the cis-trans isomerization of proline-containing peptide bonds. His findings suggest that proline isomerization of histones is a novel form of chromatin modification that regulates transcription. Long-term, his work aims to elucidate the function of newly identified chromatin-modifying enzymes, with the goal of establishing their efficacy as therapeutic targets for various diseases, including cancer.

Research Interests

Experience