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Christopher E. Rudd, Ph.D., is a professor in the Department of Medicine and the Department of Microbiology, Infectiology and Immunology at the University of Montreal. He is also the director of the Cellular Signaling in Immunotherapy research unit at the Maisonneuve-Rosemont Hospital Research Center. His research focuses on signaling pathways in T lymphocytes and how these pathways control immune functions. He has identified key complexes like CD4 and CD8-p56lck that are crucial in T cell activation. Dr. Rudd's recent work highlights mechanisms controlling T cell adhesion and movement in lymph nodes, as well as the roles of co-receptors such as CD28 and CTLA-4 in immunity. His discoveries include identifying GSK-3 as a central regulator of PD-1 expression on T cells and developing small-molecule inhibitors of GSK-3 to regulate PD-1 negatively, aiding in the clearance of viral infections. His work contributes significantly to understanding adaptive immune responses and developing therapeutics for infection, autoimmunity, and cancer.
University of Montreal • Montreal, QC, Canada
Professor in the Departments of Medicine and Microbiology, Infectiology, and Immunology.
Most programs require French B2 level; specific departments may require C1 or C2.