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Claire Mitchell's research employs physiological approaches to understand the mechanistic steps underlying disease mechanisms. Currently, her laboratory is investigating how elevated pressure leads to neuronal death, focusing on the release of ATP, pannexin hemichannels, P2X7 receptors, and the neuroprotective actions of A3 adenosine receptors. Additionally, the role of cytokine release components is being explored. Her lab also examines lysosomal physiology, particularly regulating lysosomal pH in health and disease. Pharmacological and molecular manipulation of lysosomal Cl- channels, such as CFTR and CLC-7, are used to reacidify lysosomes and improve degradative activity in aging and diseased cells. As the Director of the DScD Curriculum & Training, she provides guidance and support to DScD students, mentors thesis committees, and helps integrate clinical research training while establishing Individual Development Plans to enhance career opportunities.
University of Pennsylvania • Philadelphia, PA
Director of DScD Curriculum & Training, providing guidance and support to DScD students.
Wharton Doctoral programs cover fields like Finance, Marketing, Management, and Operations, Information and Decisions.