Dr. Claudia Doege

Biography

Claudia Doege, MD, is an Associate Professor in the Department of Pathology and Cell Biology at Columbia University. Dr. Doege's research focuses on understanding the molecular mechanisms underlying human obesity, which is a major health concern in the United States, significantly contributing to conditions such as type 2 diabetes, heart disease, liver fat deposition, and various types of cancer. Her work aims to identify therapeutically tractable hypothalamic pathways that have been previously implicated in body weight regulation, with the goal of developing novel therapeutic strategies for obesity. The strategies she employs include functional studies of novel obesity variants and genes in human stem cell-derived hypothalamic neurons, single-cell transcriptomics, and epigenomics to characterize the diversity of cell types within human hypothalamus populations that are altered in obesity. Additionally, she utilizes computational biology approaches to integrate genome-wide association study (GWAS) data and functional genomics data from human brain tissue to characterize disease-perturbed gene networks and molecular mechanisms of disease. Dr. Doege is an active member of the International Society for Stem Cell Research and the Society for Neuroscience.

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