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Coen Wiegman is a Senior Teaching Fellow in Respiratory Science at the National Heart & Lung Institute, Imperial College London. He obtained Master's degrees in Animal Physiology and Behavioral & Cognitive Sciences from the University of Groningen, Netherlands, and subsequently earned a PhD in Pediatrics from the same university. After completing his PhD, he held a post-doctoral position at Imperial College London before working as a Senior Scientist at Cambridge University in association with pharmaceutical companies Paradigm Therapeutics and Takeda. Since 2009, he has been in his current position where he initially worked under Kazuhiro Ito on HDAC2 in vivo models related to Chronic Obstructive Pulmonary Disease (COPD). Wiegman successfully completed an RC UK Academic Fellowship focusing on COPD, investigating the inflammatory mechanisms and the role of histone deacetylases as co-repressors in suppressive inflammatory gene activation to overcome corticosteroid resistance. His current research explores the role of inflammation and oxidative stress in the pathophysiology of asthma and COPD, particularly intracellular molecular mechanisms related to oxidative stress-induced changes in anti-oxidative stress response, HIF-1α signaling, and mitochondrial dysfunction.
Specialisms available in Materials for the Energy Transition or Theory and Simulation of Materials.