Dr. Colin Logie

Biography

Colin Logie is an Associate Professor in the Molecular Biology Program at Radboud University. He holds a PhD from Francis Stewart at EMBL, where he developed a prototype ligand-dependent DNA recombinase. This work demonstrated how recombination can be dependent on the presence of steroids through the use of a recombinase fused to a steroid receptor ligand binding domain, laying the groundwork for sophisticated reverse genetics techniques widely used in mice over the past decades. Following his PhD, he completed a postdoctoral fellowship with Craig Peterson at UMASS, where he reconstituted a viral transcription-factor activation domain-dependent targeting system for the fungal SWI/SNF chromatin remodeller complex using a nucleosome array made from sea urchin DNA and chicken erythrocyte histone octamers. His current research focuses on understanding how chromosomes are organized within eukaryotic nuclei and how transcription regulation occurs within this context, particularly exploring the epigenetic regulation of gene expression. He is especially interested in chromatin boundaries and the role of cis-acting elements, which define enhancer-promoter interactions within topologically associated domains (TADs). Additionally, he studies gene regulation in embryonic and hematopoietic stem cells, investigating glucocorticoid receptor activation pathways at the molecular level. His work also includes collaboration with the international Gene Ontology consortium on gene regulation annotation.

Research Interests