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Colleen McHugh is an Assistant Professor in the Department of Chemistry at the University of California San Diego, where her research focuses on RNA-protein interactions, assembly of ribonucleoprotein complexes, and structural biology of multimeric complexes. Her lab investigates the assembly and function of non-coding RNA protein complexes in human cells, integrating techniques from chemical biology, molecular biochemistry, and genomics to understand complex biological systems. Among her current projects, she studies the dysfunction of the TDP-43 protein in neurodegenerative diseases such as Alzheimer's, developing novel assays to quantify RNA-protein interactions. Additionally, her work on non-coding RNA GRAS1 explores its role in protecting against DNA double-strand breaks during cell survival and growth. McHugh also examines the epigenetic regulation of gene expression and employs quantitative mass spectrometry to analyze XIST non-coding RNA interactions. Her commitment to mentorship and outreach includes service on departmental committees and organizing events to promote women's involvement in science. She has been recognized for her mentorship within the Physical Sciences.
University of California San Diego • La Jolla, CA
Engaged in research on RNA-protein interactions and protein complexes related to human cell biology.
California Institute of Technology •
Conducted advanced research in biochemical interactions and complex biological systems.
Administered by the Scripps Institution of Oceanography. Curricular groups include Climate-Ocean-Atmosphere (COAP), Geosciences (GEO), and Ocean Biosciences (OBP).