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Constantinos Koumenis is the Richard H. Chamberlain Professor in Radiation Oncology at the Perelman School of Medicine, University of Pennsylvania. He holds a Ph.D. in Biochemistry from the University of Houston and a Bachelor's degree in Pharmacy from Aristotle University in Thessaloniki, Greece. His research focuses on the tumor microenvironment and tumor metabolism, specifically the integrated stress response and its implications for cancer treatment. Koumenis aims to develop novel and physiologically relevant animal models for incidental radiation damage, employing advanced radiation delivery technologies such as FLASH radiotherapy. His laboratory investigates the mechanisms by which components of the tumor microenvironment, such as hypoxia and nutrient availability, interact with cellular survival and apoptotic pathways to produce resistant tumor phenotypes. By understanding these survival pathways, the lab designs cell-based assays to screen small molecule libraries for potential inhibitors to improve therapeutic effectiveness. Koumenis is also interested in using biocompatible nanoparticles for drug delivery and identifying novel radiation sensitizers to enhance the efficacy of ionizing radiation for cancer therapy.
Wharton Doctoral programs cover fields like Finance, Marketing, Management, and Operations, Information and Decisions.