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Dr. Crystal S. Conn is an Assistant Professor in the Department of Radiation Oncology at the Perelman School of Medicine, University of Pennsylvania. Her research focuses on cancer biology, particularly the adaptive stress responses that cancer cells exhibit in reaction to various environmental challenges. She investigates how these signaling pathways are activated in cancer cells, enabling their survival and transformation during disease progression. This includes studying the rewiring of the translational machinery in aggressive cancer cells, which leads to the selective expression of specific mRNAs. Her work also aims to identify unique protein isoforms produced through non-conventional initiation processes that could serve as potential clinical biomarkers and therapeutic targets. Dr. Conn's lab employs various state-of-the-art techniques, including ribosome profiling and proteomics, to explore these topics, with a goal of improving treatment strategies and understanding the genetic landscape of patient samples. Through her research, she aims to advance the detection processes for diseases and enhance therapeutic targeting interventions, ultimately contributing to better patient outcomes.
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