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The Martin Lab focuses on elucidating the molecular mechanisms that promote the clearance of disease-causing proteins in neurodegeneration, particularly Huntington disease and amyotrophic lateral sclerosis. The lab aims to understand the cellular pathways known as autophagy, which deliver toxic proteins and damaged organelles to lysosomes for degradation and recycling. The research approach is highly collaborative and multifaceted, involving the identification of human single nucleotide polymorphisms (SNPs), population genetics, protein characterization, and chemical biology, utilizing high-resolution microscopy. Studies are performed using yeast, cell culture, and mouse models.
Includes fields like Clinical, Cognitive, Developmental, and Industrial/Organizational Psychology.