Dr. Dale Wigley

Biography

Professor Dale Wigley leads a team in the Section of Structural Biology at Imperial College London, focusing on how DNA damage, particularly double-strand breaks, is repaired in bacterial systems. His research delves into the complexities of DNA repair mechanisms that, when flawed, can contribute to cancer development. By investigating how bacteria manage DNA repair, Professor Wigley aims to glean insights that can be applicable to human cellular processes, with a keen interest in understanding antibiotic resistance. His work emphasizes the structure and stability of DNA, which is intricately packaged within nucleosomes, and explores how large multi-protein complexes regulate access to the genetic code during transcription and repair. The INO80 family of chromatin-remodeling enzymes is a particular area of interest for his group.

Research Interests

Experience