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Danesh Moazed is a Professor at Harvard Medical School with a focus on Cell Biology. His research primarily investigates epigenetic mechanisms that control cellular memory and genome stability in eukaryotic organisms, utilizing yeast and mammalian cell model systems. He has made significant contributions to our understanding of how heterochromatin, a silent chromatin structure, regulates gene expression and maintains genome stability through epigenetic inheritance. His work has uncovered the participation of nuclear RNA interference (RNAi) in the formation of heterochromatin and established various mechanisms through which RNAi complexes interact with nascent noncoding RNAs. These interactions lead to the degradation of heterochromatic RNAs and the recruitment of downstream chromatin-modifying complexes that help establish a stable heterochromatin environment. Furthermore, Moazed's studies highlight the critical role of RNA degradation enzymes in the maintenance of silenced chromatin. He continues to explore the roles of DNA sequences, noncoding RNAs, RNA processing pathways, and histone modifications in the larger context of epigenetic processes.
Administered by the Division of Medical Sciences (DMS). GRE is not required and will not be considered for BBS, Immunology, and Neuroscience.