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Danesh Moazed is a Professor in the Department of Cell Biology at Harvard Medical School and an investigator at the Howard Hughes Medical Institute (HHMI). He received his Ph.D. from the University of California, Santa Cruz, and conducted postdoctoral research at the University of California, San Francisco. His research lab focuses on the mechanisms of gene silencing and the inheritance of epigenetic traits across generations. The lab investigates various pathways related to heterochromatin-mediated gene silencing in both yeast and mammalian cells. Work conducted in budding yeast is centered around the structure and function of heterochromatin, particularly the role of Silent information regulator (Sir) proteins, while studies in fission yeast examine the nuclear RNA interference machinery and histone-modifying enzymes. In mammalian cells, the lab explores HP1-mediated heterochromatin formation pathways. Through the use of genetics, genomics, biochemical purification, and structural biology techniques, Moazed's research aims to uncover the fundamental principles governing the assembly, function, and epigenetic propagation of heterochromatin.
Administered by the Division of Medical Sciences (DMS). GRE is not required and will not be considered for BBS, Immunology, and Neuroscience.