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Daniel Claiborne is an Assistant Professor in the Department of Microbiology at the Perelman School of Medicine, University of Pennsylvania. His research focuses on the mechanistic determinants of T cell dysfunction in chronic infections, particularly HIV. The Claiborne lab is dedicated to understanding how chronic antigen exposure affects T cell responses and aims to develop potent T cell immunotherapies to enhance treatment for malignancies and chronic diseases. His work employs a comprehensive approach, utilizing in vivo model systems with HIV-infected humanized mice, to explore T cell function over time. By investigating the interplay between viral characteristics and T cell activation, Claiborne is seeking to optimize chimeric antigen receptor (CAR) T cell therapy for achieving functional cures for HIV. His lab emphasizes the importance of intrinsic viral replicative capacity on CAR T cell function, identifying critical challenges in developing effective immunotherapies for patients harboring high-viral replicative capacity HIV strains.
Wistar Institute • Philadelphia, PA
Teaching and conducting research in microbiology, focusing on T cell immunotherapies and chronic infections.
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