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Daniel R. Foltz, PhD, is a Professor in the Department of Biochemistry and Molecular Genetics at the Feinberg School of Medicine, Northwestern University. His research is focused on key questions related to chromosome segregation during cell division, ensuring accurate inheritance of the genome. Chromosomal instability is a hallmark of cancer that drives tumorigenesis, making the specification of centromeres a crucial biological question with significant therapeutic potential. His work emphasizes the importance of histone variant CENP-A in stable centromere inheritance, exploring mechanisms of epigenetic inheritance through a combination of cell biology, biochemical purification, and in vitro reconstitution of centromeric chromatin. The immediate research goal is to elucidate the mechanisms governing epigenetic centromere inheritance, while the long-term objective involves delineating its role in tumorigenesis, ultimately translating fundamental findings into therapeutic strategies against proliferative diseases.
Northwestern University Feinberg School of Medicine • Chicago, IL
Leading research on chromosome segregation and integrity during cell division.
Administered by The Graduate School; focuses on Biomechanics, Imaging, Biomaterials, and Regenerative Medicine.