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Daniel Kahne is the Higgins Professor of Chemistry and Chemical Biology at Harvard University, specializing in biological chemistry and molecular pharmacology. His research focuses on antibiotic resistance, a significant challenge posed by Gram-negative bacteria due to their intrinsic resistance mechanisms and the structure of their double-layered membranes. Kahne's work aims to understand the biogenesis of the cell envelope in these bacteria, particularly through the study of peptidoglycan biosynthesis and outer membrane assembly. The research group targets the assembly machinery essential for membrane integrity, seeking to uncover ways to disrupt this barrier and repurpose existing antibiotics currently ineffective against Gram-negative organisms. Kahne has published extensively on related topics, including the structural basis of lipopolysaccharide export and the mechanisms of membrane integration of beta-barrel proteins. His insights aim to provide new targets for antibiotic discovery and innovative solutions to combat resistance.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).