Dr. Daniel Kahne

Biography

Daniel Kahne is a Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard University. His research focuses on the molecular mechanisms of antibiotics and fundamental cellular processes. Kahne primarily studies drugs that target bacterial cell wall biosynthesis, including beta-lactams and vancomycin, and explores how these molecules interact with the protein machines responsible for synthesizing and degrading the bacterial cell wall. His work provides mechanistic insights into the enzymes involved in bacterial cell shape, growth, and division. Additionally, he investigates the structure of cellular membranes, particularly the asymmetric organization of lipids and proteins that is essential for proper functionality. Utilizing E. coli as a model system, Kahne has identified protein complexes vital for the assembly of glycolipids and proteins in the outer membrane of Gram-negative bacteria. His research efforts integrate organic synthesis, bacterial genetics, biochemistry, and structural biology.

Research Interests