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Daniel Nietlispach is a researcher in the Department of Biochemistry, known for his work in the field of integral membrane protein biology, focusing on the structure, dynamics, and function of lipid-embedded integral membrane proteins. His research particularly emphasizes the family of seven-helical membrane proteins, including G-protein-coupled receptors (GPCRs) and microbial rhodopsins. GPCRs, a significant group comprising approximately 850 proteins, play critical roles in relaying diverse extracellular signals to the cell membrane, thereby activating signaling cascades that result in various cellular responses. These receptors are vital for the regulation of physiological processes and represent important drug targets. Nietlispach utilizes NMR spectroscopy to characterize the dynamic nature of receptors and to investigate the mechanistic details involved in signal activation processes. His recent studies have also explored the agonist-dependent conformational landscape of the β1-adrenergic receptor and how environmental factors, such as lipids, may affect membrane protein function. Additionally, he is involved in improving NMR methodology to enhance the study of biological systems.
Standard postgraduate requirements for Department of Politics and International Studies (POLIS) and related humanities departments.