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Daniel J. Powell Jr., Ph.D., is a Professor in the Department of Pathology and Laboratory Medicine at the University of Pennsylvania. He leads the Powell Lab, which focuses on translating immunotherapy for cancer, particularly emphasizing gynecologic cancers. The lab's work involves basic T cell biology and developing T cell-based therapies for ovarian cancer, working on the generation and isolation of high-avidity, tumor-reactive T cells from heterogeneous tumor-infiltrating lymphocyte populations. This research aims to rationally design new checkpoint therapies by characterizing immune cells and their functions. The lab also develops novel tumor model systems to optimize immunotherapy strategies, including bispecific antibodies and gene transfer techniques that generate tumor-reactive T cells. Powell's team has pioneered new universal CAR T cell products to treat difficult cancers, exploring immunobiology and various therapeutic combinations to enhance antitumor immune responses. His efforts contribute significantly to the clinical translation of immunotherapy research.
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