Dr. Daniel Raleigh

Biography

Daniel Raleigh's research program combines interdisciplinary studies of pathological protein misfolding and investigations into the mechanisms of beta-cell death in diabetes. His fundamental studies focus on protein-membrane interactions in human disease, efforts in protein engineering and design, and the dynamics of protein folding. Raleigh's work on amyloid formation addresses key issues in metabolic disease, specifically pancreatic islet amyloidosis linked to islet amyloid polypeptide (IAPP). This process is crucial in understanding beta-cell stress and dysfunction, which contribute to type 2 diabetes and islet transplant failure. He employs biochemical, biophysical, and cellular biological approaches, often collaborating with experts on transgenic mouse models. Additionally, he investigates the role of protein aggregation in viral infections and the interactions of amyloidogenic proteins with membranes. His research includes innovative techniques in membrane biophysics and aims to develop tools for investigating broader fields of amyloidosis and protein folding. Raleigh also works on designing novel bioactive IAPP analogs for hormone replacement therapy in diabetes.

Research Interests

Experience