Dr. Daniel Scotcher

Biography

Dan is a Lecturer in Applied Pharmacokinetics at the University of Manchester and leads the Physiologically-Based Pharmacokinetic (PBPK) and In Vitro-In Vivo Extrapolation (IVIVE) research within the Centre for Applied Pharmacokinetic Research (CAPKR). His expertise lies in developing and applying mechanistic models to predict drug metabolism and transport in vivo through computational approaches. Dan's research primarily focuses on utilizing PBPK models to translate experimental in vitro data for predicting clinical outcomes and understanding renal disposition of drugs. He has made significant contributions to the field by exploring the impact of chronic conditions on drug pharmacokinetics, as well as modelling endogenous and imaging biomarkers related to drug transporter activity modulation. His recent works include establishing PBPK frameworks for non-CYP enzymes. Dan has a strong track record of collaboration with clinicians and pharmaceutical industry partners, contributing to both national and international projects. He serves on the editorial board of Drug Metabolism and Disposition and is the Deputy Director of the MSc in Model-Based Drug Development, where he leads the PBPK modelling and IVIVE module.

Research Interests