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Dr. Daniela Quail is an Associate Professor in the Department of Physiology at McGill University. Her research program focuses on the role of the tumour microenvironment in cancer progression, with a particular interest in how chronic inflammatory conditions affect the microenvironmental landscape of organs and alter tissue homeostasis and cancer outcomes. Her team explores key themes related to cancer types, metastatic progression, and the factors associated with patient mortality. They have found that metastatic progression is influenced by inflammatory changes in the systemic environment, which remodels the tissue landscape of distant organs and impacts seeding efficiency. Notably, obesity, affecting about 30% of adults in Canada and considered the leading preventable risk factor for cancer, is a prominent factor in their investigations. Dr. Quail's work also examines how chronic inflammation, particularly from obesity, influences common secondary organs such as the lung, liver, brain, and bone, ultimately affecting cancer metastasis. Furthermore, her research delves into the unique challenges posed by the blood-brain barrier in brain tumors, where immune privilege is compromised, leading to significant changes in immune cell infiltration and its impact on cancer outcomes.
Department: Department of Medicine. Program: Experimental Medicine.