Dr. Daniele Biasci

Biography

Daniele Biasci is a Group Leader on the Innovation Investigator track at A-TAP Data Science. His research primarily focuses on deciphering the genetic architecture of Tertiary Lymphoid Structures (TLS) formation. These structures are highly organized aggregates of immune cells that spontaneously form in non-lymphoid tissues, resembling secondary lymphoid organs. He investigates their significant role in adaptive immunity and how their prevalence varies among individuals, impacting diverse clinical outcomes in various malignancies and immune-mediated diseases. For example, TLS has been linked to favorable prognosis in cancers like melanoma and renal cancer, with increased abundance correlating with enhanced responsiveness to immune checkpoint inhibitors. In contrast, in Immune-Mediated Inflammatory Diseases, TLS development might exacerbate immune responses, contributing to tissue damage and disease progression. His research team aims to elucidate the biological pathways driving TLS formation, hypothesizing that germline genetic variations account for the variability observed in TLS development. By leveraging large datasets paired with RNA/DNA sequencing from notable cancer genomics projects, they scrutinize gene expression patterns and simultaneously seek genetic variants connected to TLS formation in the tumor microenvironment. Ultimately, the goal is to uncover genetic determinants that influence TLS development and maintenance, contributing to the advancement of targeted interventions and enhancing management of diseases where TLS play a crucial role.

Research Interests

Experience