Dr. Darerca Owen

Biography

Darerca Owen's research revolves around Small G protein-regulated signalling networks, particularly the Ras superfamily which are essential components in the processes of cell biology. Her group focuses on understanding the structures and functions of Small G proteins, which are significantly involved in controlling intricate networks of intracellular signalling pathways. Interestingly, these pathways are often found to be deregulated in various disease states, including cancer. The Owen Group primarily studies the Ras and Rho families of small GTPases to comprehend the complex interconnected networks that these proteins control at a molecular level. A central aspect of her research is to achieve a complete understanding of the Cdc42-ACK signalling system and its contribution to disease states, with aims to develop safe and effective drugs targeting these pathways. Key research questions include the therapeutic targeting of the Cdc42-ACK signalling axis, the potential utilisation of peptide biologics for Ras-driven cancers, and the specificity of small G protein-effector complex interactions.

Research Interests