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David Allman, Ph.D., is a Professor in the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine, University of Pennsylvania. His research focuses on various aspects of antibody-secreting plasma cells, which are essential for host protection and are involved in chronic transplant rejection, autoimmunity, and multiple myeloma. The laboratory aims to define unique biosynthetic pathways that allow plasma cells to survive and maintain antibody titers, exploring how B cells activate, divide, and build the endoplasmic reticulum (ER) necessary for large antibody secretion without resulting in cell death. Current projects involve investigating the regulation of ER function in long-lived plasma cells versus malignant plasma cells and understanding the extrinsic factors in the bone marrow that influence plasma cell survival.
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