Dr. David Calderwood

Biography

David Calderwood is a Professor in the Department of Pharmacology at Yale University. His research focuses on integrins, which are essential heterodimeric adhesion receptors that mediate cell-cell and cell-substratum adhesion. With a strong emphasis on the role of integrin cytoplasmic tails in signaling pathways and cellular responses, his studies have revealed critical insights into the molecular mechanisms underlying cell migration, adhesion, and the assembly of the extracellular matrix. By investigating the interactions between integrins and cytoskeletal networks, Calderwood's work highlights the importance of tight regulation of integrin activation in processes such as angiogenesis, tumor cell metastasis, and immune responses. His ongoing research includes structural-functional studies on integrin-linked kinase and its interactions with kindlins, aiming to further elucidate the complex signaling pathways involved in cell behavior. Calderwood has contributed significantly to the understanding of how various proteins regulate integrin activation and, consequently, cell migration, which has implications for both health and disease.

Research Interests