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David Cohen is a Professor of Medicine and the Chief of the Division of Gastroenterology, Hepatology and Endoscopy at Brigham Women's Hospital. His research focuses on understanding the molecular and cellular mechanisms whereby intracellular membrane lipid composition regulates lipid and glucose metabolism in health and disease. His work specifically investigates phosphatidylcholines (PC), a abundant lipid class found in membrane bilayers, which consists of fatty acids linked to a glycerol molecule. Cohen's research has shown that variations in PC molecular species influence membrane fluidity and metabolic control, particularly under physiological stress and in conditions such as non-alcoholic fatty liver disease (NAFLD). He has demonstrated that the phosphatidylcholine transfer protein (PC-TP) plays a pivotal role in regulating hepatic lipid glucose metabolism. Recent studies also highlight the importance of ACOT family proteins in controlling metabolic fates of fatty acids, further emphasizing the connection between lipid metabolism and insulin resistance.
Brigham Women's Hospital • Boston, MA
Oversees the division responsible for clinical and research activities in the fields of gastroenterology, hepatology, and endoscopy.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).