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David R. Lynch is a Professor in the Department of Neurology at the University of Pennsylvania. His research primarily focuses on the NMDA (N-methyl D-aspartate) receptors, exploring their roles in excitotoxicity and various neurological conditions. He investigates how excitotoxicity leads to neuronal damage in scenarios such as cerebral ischemia and prolonged seizures, emphasizing the complex mechanisms involving calcium entry through specific glutamate receptors. Dr. Lynch's work has implications for developing neuroprotective agents and anticonvulsants, highlighting the therapeutic potential of NMDA receptor antagonists despite their complicated side effects. His efforts also involve examining the pharmacological specificity of NMDA receptor subtypes to create selective therapeutic agents aimed at mitigating excitotoxic effects in human diseases. He employs systematic approaches to explore the physiological and pharmacological properties of NMDA receptors and their role in excitotoxic processes.
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