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David Marcinek received his PhD from Stanford University, where he studied muscle metabolism in endothermic and ectothermic fish species. After completing his PhD, he joined the University of Washington as a postdoctoral fellow working with Kevin Conley, where he developed nuclear magnetic resonance and optical spectroscopy tools to study the effects of age on skeletal muscle energetics. Upon becoming faculty in the Department of Radiology, Marcinek has focused his research on the interaction between mitochondrial oxidative stress and energy metabolism in both health and disease. His research interests highlight the critical role of mitochondria in cellular energetics and cell survival, particularly in the context of aging and degenerative diseases. He has developed novel methods to directly measure mitochondrial function in vivo using optical and magnetic resonance spectroscopies, allowing for independent measurements of oxygen and ATP fluxes in intact animals. His current research focuses on identifying the role of mitochondrial dysfunction in the loss of energy homeostasis and its implications for aging and disease, as well as the toxicity of various xenobiotic compounds and chemotherapeutic agents on mitochondrial health.
University of Washington • Seattle, WA
Developed NMR and optical spectroscopy tools to study skeletal muscle energetics.
Department of Radiology, University of Washington • Seattle, WA
Focused on mitochondrial oxidative stress and energy metabolism.
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