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David Stuart Millington is a Professor Emeritus of Pediatrics at Duke University. He has made significant contributions to the development of innovative mass spectrometric methods for analyzing disease-specific metabolites in human physiological fluids, which are essential for diagnosing inborn errors of metabolism. Millington has been instrumental in developing automated methods utilizing tandem mass spectrometry for the analysis of metabolites in blood spots and urine of neonates, greatly enhancing newborn screening methodologies. His research also includes the development of mass spectrometry-based biomarker assays that monitor treatment and diagnosis of lysosomal storage diseases (LSDs). Furthermore, he has worked on 'lab-on-a-chip' technology that employs digital microfluidics for enzymatic DNA assays, applicable in point-of-care newborn screening. Over his career, Millington has focused on new methodologies to study glucose metabolism both in vivo and in vitro using stable isotope labeling coupled with tandem mass spectrometry. His work on analyzing urine markers of oxidative stress using this technology has also been pivotal.
Duke University • Durham, NC
Served as a Professor in the Department of Pediatrics, contributing to pediatric research and education.
Duke University • Durham, NC
Conducted extensive research in pediatric mass spectrometry applications.
Duke University • Durham, NC
Involved in pediatric research initiatives related to metabolic disorders.
Department of Biomedical Engineering (MS program)